Original Research Article
Year: 2023 | Month: January-March | Volume: 8 | Issue: 1 | Pages: 153-157
DOI: https://doi.org/10.52403/ijshr.20230121
Effect of Tranexamic Acid on Coagulation Profile in Patients Undergoing Brain Tumour Resection Surgery
Rameesa Batul1, Meryem Juwhyreeyeh1, Bashir Ahmad Dar2, Rahid Rasool3,Ouber Qayoom4
1Senior Resident, Department of Anaesthesia, SKIMS Soura, J&K, India
2Professor, Department of Anaesthesia, SKIMS Soura, J&K, India
3Medical Officer, J&K Health and Family Welfare Department, India
4Senior Resident, Department of Cardiology, GMC Jammu, J&K, India
Corresponding Author: Ouber Qayoom
ABSTRACT
Introduction; The majority of researchers currently believe that the haemostatic anomalies in brain tumour resection patients undergoing surgery are caused by hyperfibrinolysis, either primary or subsequent to a condition of disseminated intravascular coagulation. This Study explored the changes in haemostatic profile occurring during surgery for primary brain tumours and effect on Tranexamic acid on coagulogram.
Aims & objectives:To study effect of tranexamic acid on coagulation profile in brain tumour resection patients.
Materials & methods: Patients of either sex, aged 18-65 years were randomly allocated to either group - the study group and the control group (30 patients in each group) using computer generated random numbers in sealed envelopes. The investigator was present during the procedure for data collection purpose only and was not involved in the conduct of anaesthesia. Blood samples were collected preoperatively, 6hrs postoperatively and 24hrs postoperatively for coagulogram; fibrinogen levels; platelet count; D-dimer levels
Results: In our study we found that there were no significant differences in PT, INR, aPTT, D- dimer preoperatively and at 6 and 24 hrs postoperatively. However, fibrinogen levels increased in tranexamic group and significantly decreased in saline group as compared to preoperatively.
Conclusion: Tranexamic acid prevented decrease in levels of fibrinogen and even increased levels fibrinogen significantly during the operative and postoperative period in brain tumour resection surgery.
Keywords: Coagulation profile, Meningioma