Review Article
Year: 2022 | Month: October-December | Volume: 7 | Issue: 4 | Pages: 164-172
DOI: https://doi.org/10.52403/ijshr.20221023
Contribution of Phosphodiesterase-5 (PDE5) Inhibitors in the Various Diseases
Shivendra Kumar1, Dr. Mayank Kulshreshtha2, Sunam Saha3, Shiv Shankar4, Kuldeep Singh5, Shiv Kumar6, Monika Singh7
1,2,3,4,5,6,7Rajiv Academy for Pharmacy, NH#2, Mathura, Uttar Pradesh, INDIA
5Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, INDIA
Corresponding Author: Sunam Saha
ABSTRACT
The PDE-5 inhibitors, i.e., phosphodiesterase-5 inhibitors like sildenafil, vardenafil, and tadalafil, are the most used in premature erectile dysfunction. Many literature reviews suggest that these classes of drugs are commonly used in erectile dysfunction. Many of these reviews suggest that these inhibitors (PDE-5) are used in many other diseases apart from erectile dysfunction. So, in this review, we find the main mechanism of action of PDE-5 inhibitors in different disease conditions. These inhibitors have a major role in different diseases like erectile dysfunction, memory enhancement, cancer (cell proliferation), lower urinary tract symptoms, and pulmonary arterial hypertension. This class of drug also acts through the cGMP pathway. We found that cGMP plays an important role in different diseases like erectile dysfunction, cancer, and memory enhancement. So, in this review, we show the mechanism of PDE-5 inhibitor in different disease conditions.
Keywords: PDE-5, Erectile dysfunction, Memory enhancement, cGMP, Pulmonary arterial hypertension.