Original Research Article
Year: 2022 | Month: April-June | Volume: 7 | Issue: 2 | Pages: 53-63
DOI: https://doi.org/10.52403/ijshr.20220409
Serum Homocysteine Level in Patients of Type 2 Diabetes Mellitus with Macrovascular Complications
Dr. Abbas Naqvi1, Dr. A.K.Shadani2, Dr. Shubhangi Gupta3, Dr. I.Rahman4, Dr. Varsha Vishwakarma5
Department of Medicine, Ramakrishna Care Hospital, Raipur, India.
Corresponding Author: Dr. A.K.Shadani
ABSTRACT
The risk of CVD in men with DM is 3-fold and in women with DM 5-fold in comparison to those without diabetes(1). Diabetes is a recognized independent risk factor for stroke and is associated with higher morbidity and mortality(2-4). The severity and duration of DM are important predictors of both the incidence and the extent of PAD, as observed in United Kingdom Prospective Diabetes Study, where each 1% increase in glycosylated hemoglobin was correlated with a 28% increase in incidence of PAD, and higher rates of death, microvascular complications and major amputation.(5,6)
Homocysteine concentration is found to be higher in patients with peripheral vascular, cerebrovascular and coronary artery diseases than those without such diseases.(7)
This observational comparative study was done at Ramakrishna Care Hospital, Raipur, from January 2017 to June 2018 involving 100 type 2 diabetes mellitus patients.
Patients were divided into two groups-
Group 1: The Case Group- Type 2 DM patients with macrovascular complications.
Group 2: The Control Group - Type 2 DM patients without any macrovascular complications
With the help of Clinical evaluation and detailed investigations we had determined the presence of macrovascular complications in which we had included Myocardial infarction, CVA and Peripheral vascular disease. Data obtained from these patients were analysed and the results were compared with prior studies of similar objectives. Higher age and duration of diabetes thus had a positive correlation with macrovascular disease. The mean serum homocysteine level was statistically significant and they correlate with higher incidence of macrovascular disease in males and with increasing age.
Keywords: Type 2 Diabetes Mellitus, DM, CVD, CVA, Serum Homocysteine Level, Macrovascular Complications.