Original Research Article
Year: 2021 | Month: January-March | Volume: 6 | Issue: 1 | Pages: 89-94
The Effect of Cisplatin Chemotherapy on Ototoxicity Event in Retinoblastoma Patients
Eka Savitri1, Deti Fitria2, Amsyar Akil3, Dasril Daud4, Nadhirah Rasyid5, Abdul Kadir6
1Department of Ear, Nose, Throat, Head-Neck Surgery, Medical Faculty,
Hasanuddin University, Makassar, Indonesia.
2Department of Ear, Nose, Throat, Head-Neck Surgery, Medical Faculty,
Hasanuddin University, Makassar, Indonesia.
3Department of Ear, Nose, Throat, Head-Neck Surgery, Medical Faculty,
Hasanuddin University, Makassar, Indonesia.
4Department of Child Health, Medical Faculty, Hasanuddin University, Makassar, Indonesia.
5Department of Child Health, Medical Faculty, Hasanuddin University, Makassar, Indonesia.
6Department of Child Health, Medical Faculty, Hasanuddin University, Makassar, Indonesia.
Corresponding Author: Dharmeshkumar B Kheni
ABSTRACT
Background: Chemotherapy is one of the cancer treatments recommended as a first line in neck head cancer, one of which is cisplatin with frequent side effects ototoxic. Retinoblastoma is a neoplasm originating from neuroretina or glía cells that are malignant in children, especially under 5 years old. Various therapies are carried out, one of which is chemotherapy. Ototoxicity due to the use of cisplatin is a side effect that must be taken into account and requires the best early detection and monitoring.
Objective: This study aimed to assess and compare the function of cochlear hair cells with OAE examination before and after chemotherapy in retinoblastoma grade III and IV patients
Materials and Methods: This study was conducted using cohort prospective technique on 22 patients each sample was examined with OAE. OAE examination done before and after cisplatin chemotherapy in retinoblastoma stage III and IV
Results: The result showed that before and after administration of chemotherapy, all groups both stage III and stage lV did not change, the results were normal for all subjects with pass value
Conclusion: The function of the cochlear hair cell based on DPOAE examination in patients with stage III and IV retinoblastoma at each frequency obtained a pass value which meant that no cochlear hair cell damage which indicated no occurrence of ototoxicity and there were no significant differences of cochlear hair cell function between patients with stage III and IV retinoblastoma after receiving cisplatin chemotherapy.
Keywords: Cisplatin, ototoxicity, retinoblastoma.