Original Research Article
Year: 2020 | Month: October-December | Volume: 5 | Issue: 4 | Pages: 196-200
Antimicrobial Susceptibility Testing for Corynebacterium pseudodiphtheriticum
Rudi Hendro Putranto1, Kambang Sariadji2, Khariri3
1,2,3Center for Biomedical and Basic Technology of Health, National Institute of Health Research and Development Technology, Health Research and Development Body, Health Ministry of RI
(National Institute of Health Research and Development, NIHRD Jakarta)
Corresponding Author: Rudi Hendro Putranto
ABSTRACT
Background: Corynebacterium pseudodiphtheriticum is harmless to humans and only part of commensal in the upper respiratory tracts and skin. Nevertheless Over the last two decades C.pseudodiphtheriticum has been reported was caused disease in humans, particularly in patients with impaired immunity. Currently information about C.pseudodiphtheriticum resistance in Indonesia is still limited.
Objectives: This study aims to determine patterns of resistance and the effectiveness of some antibiotics against C.pseudodiphtheriticum.
Method: The determinations of antibiotic resistance pattern are performed by using diffusion disc agar methode. using the medium Muhler hilton with the addition of 5% sheep blood. The results of antibiotic susceptibility testing for C.pseudodiphtheriticum showed all isolates resistance to erythromycin and tetrasikline.
Results: There are two isolates showed resistance against to penicillin. In contrary all isolates are sensitive to ciprofloxacin and ceftriaxone. Resistance profile also showed multi drug resistance against to 2, 3, 4 and 7 antibiotics such as penicillin, moxifloxacin, gentamicin, vancomycin, tetracyclines, clindamycin and linezolid.
Conclusion: There are monoresistant C. pseudodiphtheriticum and multi-drug resistant to some antibiotics.
Keywords: Corynebacterium pseudodiphtheriticum, Antimicrobial, Resistance