Original Research Article
Year: 2020 | Month: July-September | Volume: 5 | Issue: 3 | Pages: 180-185
Is there any Association between Serum 25 (OH) Vitamin D3 Level and Hypothyroidism among Females: A Cross Sectional Study
Meenakshi Shankar1, Mukul Singh2
1Senior Resident, 2Professor,
Department of Pathology, Vardhman Mahavir Medical College& Safdarjung Hospital, New Delhi, India,
Corresponding Author: Mukul Singh
ABSTRACT
Background: Hypovitaminosis D is a global health problem where over a billion people are affected. Few studies have been done in past to assess the association between vitamin D status and hypothyroidism but yielded conflicting results. The aim of this study was to investigate correlation of serum (25-OH) D3 level among females with hypothyroidism and healthy controls.
Materials and Methods: This was a cross sectional study and total of 90 women were enrolled in it for analysis. 45 recently diagnosed hypothyroid female patients were included in group I (case) and 45 healthy females were recruited in group II (control). Serum 25(OH) D3, T3, T4 and TSH were measured in all participants.
Results: While there was no significant difference in the age compared with the controls. Cases had significantly higher TSH, had significantly lower T4 and there was no significant difference in T3 levels. We found significant difference in the mean 25(OH) Vitamin D levels in hypothyroid females than in healthy females (15.44±4.65 vs 20.91±7.98, p=0.000). Furthermore, 100% hypothyroid and 79.9% healthy females had vitamin D levels <30ng/ml. We found inverse insignificant correlation between 25(OH)D3 and TSH in the hypothyroid group was also seen with (r = -0.060, p 0.695).
Conclusion: We conclude that there is no correlation of serum (25-OH)D3 levels among females with hypothyroidism and healthy controls.
Keywords: Females, hypothyroidism, vitamin D deficiency