Year: 2024 | Month: October-December | Volume: 9 | Issue: 4 | Pages: 346-356
DOI: https://doi.org/10.52403/ijshr.20240441
Impact of Low-Dose Prednisolone on Pregnancy Viability in Women with Recurrent Pregnancy Loss of Unexplained Etiology
Mahmuda Ehsan
Department of Obstetrics and Gynecology, International Medical College and Hospital, Gazipur, Bangladesh
ABSTRACT
Recurrent pregnancy loss (RPL) of unexplained etiology presents a significant challenge in reproductive medicine, often leaving affected women with limited treatment options. Emerging evidence suggests that immunological factors may play a role in unexplained RPL, and corticosteroids like low-dose prednisolone could improve pregnancy outcomes by modulating immune responses. This retrospective cohort study examined the impact of low-dose prednisolone on pregnancy viability in women with a history of unexplained RPL. Medical records from reproductive health clinics were analyzed to compare outcomes between women receiving low-dose prednisolone (≤10 mg daily) and those not receiving any immunosuppressive treatment. Results demonstrated a statistically significant increase in pregnancy viability rates (68% in the prednisolone group vs. 45% in the non-treatment group, p < 0.05) and a decrease in miscarriage rates (30% vs. 55%, p < 0.01) among women using prednisolone. Furthermore, no significant differences in adverse maternal or fetal outcomes were observed, supporting the safety profile of low-dose prednisolone. The findings suggest that low-dose prednisolone may effectively improve pregnancy viability by modulating immune activity without substantial risks. However, further randomized controlled trials are needed to confirm these results and explore specific immunological pathways. This study underscores the potential of low-dose prednisolone as a promising treatment for unexplained RPL, offering new hope for affected women and paving the way for more targeted therapies in reproductive medicine.
Keywords: Recurrent Pregnancy Loss, Low-Dose Prednisolone, Unexplained Pregnancy Loss, Immunomodulation, Pregnancy Viability, Miscarriage Reduction, Reproductive Immunology