Original Research Article
Year: 2019 | Month: July-September | Volume: 4 | Issue: 3 | Pages: 27-31
Deranged Liver Function Tests in Type 2 Diabetes: A Retrospective Study
Dr Aditi Singh1, Dr Deepika Dalal1, Dr Ashish Kumar Malik2, Dr Anuj Chaudhary3
1Demonstrator, Department of Biochemistry, Pt B D Sharma Post graduate Institute of Medical Sciences.
2Senior Resident, Department of Psychiatry, Pt B D Sharma Post graduate Institute of Medical Sciences.
3Consultant, Jeet hospital, Guhana, Rohtak,
Corresponding Author: Dr Deepika Dalal
ABSTRACT
Background: Liver associated disorders like altered LFTs such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyltranspeptidase (GGT) in the serum, fatty liver disease, cirrhosis, hepato-cellular carcinoma and acute liver failure are a common occurrence in type 2 DM.
Aim and Objective: To assess the association between liver function parameters and type 2 diabetes (T2D) in a north Indian population.
Material and Methods: The study was conducted among 133 Type 2 DM patients in the department of Biochemistry, Pt. B.D Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India. Data from type 2 DM diagnosed patients was retrospectively reviewed. Reports of outpatient fasting serum glucose and LFTs (which included serum levels of total bilirubin, AST, ALT, ALP, and albumin) were compiled. LFTs were advised to these patients as a part of routine screening.
Results: It was found that the frequencies of elevated Bil, elevated ALT, elevated AST, elevated ALP and diminished albumin were 31.5%, 52.6%,59.3%, 42.1% and 73.6% respectively in the Type 2 DM cases. Moreover, the concentration of S. ALP correlated significantly with the random serum glucose levels. The correlation was significantly positive in the diabetic cases (r = 0.20, P < 0.05).
Conclusion: The current study highlights the importance of liver function monitoring in patients with type 2 DM. This report would be helpful inencouraging the clinicians to give interest in monitoring this neglected diabetic hepatic complication in individuals suffering from type 2 DM.
Keywords: Type 2 Diabetes, liver function, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, diabetes mellitus.