Year: 2026 | Month: April-June | Volume: 11 | Issue: 2 | Pages: 161-169
DOI: https://doi.org/10.52403/ijshr.20260220
A Prospective Randomized Study to Evaluate if Cyanoacrylate Glue is Superior Over Traditional Suturing in Laparoscopic Port Site Skin Closure
Ruchitha R. Ligade1, Sadashiv V. Patil2, K.N. Vijay Kumar3, Bathina Neehaar4
1,3,4Postgraduate in Department of General Surgery, Sapthagiri Institute of Medical Sciences and Research Centre, Bangalore, India.
2Professor, Department of General Surgery, Sapthagiri Institute of Medical Sciences and Research Centre, Bangalore, India.
Corresponding Author: Dr. Ruchitha R. Ligade
ABSTRACT
Background: The selection of an appropriate skin closure technique holds paramount importance in determining postoperative outcomes, including pain intensity, wound infection, and cosmetic results. While conventional suturing remains widely practiced, it carries inherent disadvantages such as prolonged operative time, postoperative discomfort, and mandatory suture removal visits. Cyanoacrylate tissue adhesives have emerged as a promising alternative, offering expedited application and enhanced patient experience. This investigation sought to compare the clinical effectiveness of cyanoacrylate glue against traditional suturing for laparoscopic port site skin closure.
Methods: A prospective randomized controlled trial was performed on 60 patients scheduled for elective laparoscopic procedures. Participants were randomly allocated into two equal groups: Group A (cyanoacrylate adhesive, n=30) and Group B (standard suturing, n=30). Primary endpoints included wound closure duration, postoperative pain evaluated via Visual Analog Scale (VAS) at 12, 24, 48, and 72 hours and day 7, and surgical site infection graded by the Southampton scoring system. Data were statistically analyzed using SPSS software, with a significance threshold of p<0.05.
Results: The mean wound closure time was markedly shorter in the adhesive group (1.8 ± 0.5 min) relative to the suture group (5.6 ± 1.2 min) (p<0.001). VAS pain scores were consistently reduced in Group A at all assessment time points; scores at 12 hours were 3.2 ± 1.1 versus 5.8 ± 1.4 in Group B (p<0.001). Additionally, the surgical site infection rate was lower in the adhesive group (6.7%) compared to the suture group (20%) (p=0.04).
Conclusion: Cyanoacrylate tissue adhesive demonstrated superiority over conventional suturing in laparoscopic port site closure, yielding significant benefits in operative efficiency, postoperative pain management, and wound infection prophylaxis. This modality warrants consideration as a safe, effective, and patient-centered option in minimally invasive surgery.
Keywords: Cyanoacrylate tissue adhesive, Laparoscopic surgery, Port site closure, Postoperative pain, Wound infection