Year: 2026 | Month: April-June | Volume: 11 | Issue: 2 | Pages: 61-70
DOI: https://doi.org/10.52403/ijshr.20260208
Serum Lipoprotein(a) and Lipid Profile as Predictors of Cardiovascular Risk in Non-Dialysis-Dependent Chronic Kidney Disease: A Case-Control Study
Arju Saikia1, Roshmi Rekha Gogoi2, Syeda Mohsina Rohman3
1Assistant Professor, Department of Biochemistry, Pragjyotishpur Medical College and Hospital, Guwahati, Assam, India.
2Assistant Professor, Department of Emergency Medicine, Nagaon Medical College and Hospital, Nagaon, Assam, India.
3Professor and Head, Department of Biochemistry, State Cancer Institute, Gauhati Medical College and Hospital, Guwahati, Assam, India.
Corresponding Author: Arju Saikia
ABSTRACT
Background: Chronic kidney disease (CKD) is associated with a markedly elevated risk of cardiovascular morbidity and mortality. Dysregulated lipoprotein metabolism, particularly elevated serum lipoprotein(a) [Lp(a)], may be a critical mediator of this risk.
Objectives: To compare serum Lp(a) levels and lipid profile between non-dialysis-dependent CKD patients and healthy controls, and to assess correlations between Lp(a) and other biochemical markers.
Methods: 40 non-dialysis-dependent CKD patients (CKD stages 1–4) attending Gauhati Medical College & Hospital and 40 age- and sex-matched healthy controls were enrolled for the study. Fasting serum Lp(a) was measured by sandwich ELISA; lipid profile, renal function tests, liver enzymes, and fasting plasma glucose were measured enzymatically. Unpaired Student's t-test and Pearson's correlation coefficient were used for statistical analysis.
Results: Serum Lp(a) was significantly higher in CKD cases (47.54 ± 10.40 mg/dL) compared to controls (18.56 ± 5.54 mg/dL; p<0.0001). Total cholesterol, triglycerides, LDL, and VLDL were all significantly elevated in CKD patients (p<0.05). Lp(a) showed significant positive correlations with serum urea (r=0.51), creatinine (r=0.45), total cholesterol (r=0.40), triglycerides (r=0.77), VLDL (r=0.77), and LDL (r=0.45); and a significant negative correlation with HDL (r=−0.43).
Conclusion: Serum Lp(a) is markedly elevated in non-dialysis-dependent CKD patients and correlates significantly with markers of renal dysfunction and atherogenic dyslipidemia. Routine estimation of Lp(a) may facilitate early identification and prevention of cardiovascular complications in CKD patients.
Keywords: Chronic kidney disease; Lipoprotein(a); Lipid profile; Cardiovascular risk; Dyslipidemia; Atherosclerosis