Year: 2026 | Month: January-March | Volume: 11 | Issue: 1 | Pages: 138-146
DOI: https://doi.org/10.52403/ijshr.20260116
Functional Nutrition Management of Celiac Disease and H. pylori with Fatigue in a 33-Year-Old Female: A Case Report
Snigdha Ranjan1, Maneesha Rana2, Saloni Kulkarni3, Mugdha Pradhan4
1M.Sc., Researcher, Thrivetribe Wellness Solutions Private Limited
2M.Sc., Functional Nutritionist, Thrivetribe Wellness Solutions Private Limited, Pune, India
3M.Sc., Functional Nutritionist, Thrivetribe Wellness Solutions Private Limited, Pune, India
4M.Sc., Expert Functional Nutritionist, Thrivetribe Wellness Solutions Private Limited, Pune, India
Corresponding Author: Snigdha Ranjan
ABSTRACT
Background: Celiac disease is an immune-mediated disorder characterized by intestinal inflammation, malabsorption, and systemic manifestations. Coexisting Helicobacter pylori infection may further disrupt gastric and digestive function, contributing to nutrient deficiencies and persistent symptoms.
Case Presentation: A 33-year-old underweight female presented with chronic fatigue, low energy, bloating, indigestion, constipation, disturbed sleep, and progressive weight loss. Investigations showed positive tissue transglutaminase IgA, H. pylori IgG seropositivity, anemia, elevated ESR, low vitamin D and B12 levels, high homocysteine, and low free T3. She followed a six-month functional nutrition program involving a strict gluten-free anti-inflammatory diet. Dairy, refined sugars, and seed oils were removed. Gut-supportive foods were emphasized. She received targeted micronutrient supplementation and herbal and probiotic support for H. pylori. Lifestyle measures focused on sleep, hydration, stress reduction, and strength training were also followed.
Discussion: After six months, laboratory markers showed improvement. Vitamin D rose from 12.6 to 48 ng/mL. Homocysteine decreased from 23.75 to 14.56 µmol/L. ESR declined from 35 to 10 mm/hr. Hemoglobin and vitamin B12 increased. Thyroid markers and C-peptide improved. Tissue transglutaminase IgA moved toward the negative range, and H. pylori IgG levels declined. The patient reported better energy, improved digestion, more regular bowel movements, better sleep, and weight gain.
Conclusion: This case illustrates that a structured functional nutrition protocol addressing dietary triggers, micronutrient repletion, microbial balance, and lifestyle factors was associated with meaningful clinical and biochemical improvement over six months.
Keywords: Celiac disease, H. pylori, Functional nutrition, Gut inflammation, Micronutrient deficiency, Fatigue