Year: 2025 | Month: October-December | Volume: 10 | Issue: 4 | Pages: 195-202
DOI: https://doi.org/10.52403/ijshr.20250428
Comparison of Effectiveness of Single Dose Early Ceftriaxone for Elective Caesarean Section Before Skin Incision Versus Late Ceftriaxone After Cord Clamping in Prevention of Post-Operative Infectious Morbidity
Bhagyashree1, Pratima2
1Tutor/Senior Resident, 2Associate Professor,
Department of Obstetrics & Gynaecology, Sri Krishna Medical College and Hospital, Muzaffarpur, Bihar, India
Corresponding Author: Pratima
ABSTRACT
Introduction: The likelihood of infection is between five and twenty times greater for women undergoing caesarean sections compared to those delivering vaginally. The regular use of prophylactic antibiotics reduces the likelihood of post-caesarean infection by more than 50% compared to baseline rates. This study was conducted to compare effectiveness of ceftriaxone before skin incision versus ceftriaxone after cord clamping with respect to post-operative maternal or neonatal morbidity.
Materials and Method: 150 women scheduled for elective caesarean sections were randomized into two groups: EC and LC. Subjects in group EC received an early single iv dose of ceftriaxone, one gram, 30 to 60 minutes prior to skin incision. Subjects in group LC received late ceftriaxone at the same dosage via intravenous administration immediately following cord clamping. The comparison was made among two groups for “post-operative infectious morbidity”, including pyrexia and the incidence of surgical site infections, as well as new-born outcomes like neonatal sepsis as well as the necessity for resuscitation.
Results: Pyrexia was significantly more prevalent in Group LC, with 29.33% of patients affected compared to 9.33% in Group EC (p = 0.003). Other complications, such as superficial surgical site infections (SSI) with induration and erythema, purulent discharge, serosanguinous discharge, and deep incisional SSI, were less frequent in EC group but showed no statistically significant differences between the two groups, with p-values of 0.43, 0.08, 0.40, and 0.50, respectively.
Conclusion: The administration of ceftriaxone prior to skin incision has led to a modest reduction in infection morbidity following cesarean section compared to administering the antibiotic post-cord clamping.
Keywords: Antibiotic Prophylaxis, Caesarean section, Ceftriaxone, Neonatal outcomes, Surgical Site Infection.