Original Research Article
Year: 2019 | Month: January-March | Volume: 4 | Issue: 1 | Pages: 356-361
Recent Trends in Clinical Presentation in Cases of Dengue Presenting At Tertiary Care Hospital
Dr. Manoj Kumar1, Dr. Rajesh Kumar Verma2, Dr. Deepak Kumar3, Mr. Bishal4
1Research Scientist, 2Professor& Head, 3MD student (Junior Resident), 4Research Assistant,
Department of Microbiology, UP University of Medical SciencesSaifai, Etawah U.P., India-260130.
Corresponding Author: Dr. Rajesh Kumar Verma
Introduction: The dengue virus is transmitted to man by the bite of the mosquito (Aedes aegypti and Aedes albopictus). The cases are increasing year on year basis with significant rate of morbidity and mortality in different parts of the country. These cases often present with varied spectrum of clinical signs and symptoms during the course. Recently it has been observed that these classical symptoms are shifting to less common ones with increase in their severity.
Objective: To study the shift in paradigm of clinical presentations and their severity in the cases presenting to this Tertiary Care Hospital.
Materials and Methods: All clinically suspected cases during study period 2016-17, attending different OPDs or admitted to indoor of different clinical departments, were enrolled in this study and their sera samples were subjected to NS1 antigen and IgM antibody ELISA. Of the total 562 suspected cases, 119 cases were positive either by NS1 antigen or IgM ELISA or both.
Results: The majority of these cases were males 92 (77.3%) and the most susceptible age group was 19-25 years followed by 26-35 years. The fever was commonest presentation in 118 (99.2%) cases followed by headache and abdominal pain in 76 (63.8%), myalgia in 52 (43.7%), vomiting in 44 (37%), and joint pain in 36 (30.2%) cases. In present study we observed 89 (74.8%) cases of dengue with fever, 26 (21.8%) cases with hemorrhagic manifestations and 4(3.4%) cases with presentations of shock.
Conclusion: Upon the analysis of the results, it was observed that there is shift in clinical presentations of the cases. Beside fever being the predominant symptom, abdominal pain, headache and vomiting are next common.
Keywords: Dengue, NS1 antigen and IgM antibody