Original Research Article
Year: 2018 | Month: July-September | Volume: 3 | Issue: 3 | Pages: 112-117
Assessment of Antihypertensives Drug Class in Type 2 Diabetes and its Complications
Margreth Philbert1, Binai K Sankar2
1Pharm D PB Intern, Department of Pharmacy Practice Acharya & B.M. Reddy College of Pharmacy, Bangalore Soldevanahalli, Achitnagar (Post), Hesaraghatta Main Road, Bangalore – 560 107
2Dr. B. R. Ambedkar Medical College and Hospital, RT Nagar Bangalore-560032
Background: Hypertension and Diabetes are now serious public and worldwide health challenge as by 2025 it has been estimated that 1.56 billion world populations will suffer from hypertension and diabetes is the 8thleading cause of death.
Objectives: Primary objective is assessment of antihypertensive drug classes used in type 2 diabetes & it’s complications and Secondary objectives are , is to assess the prescribing pattern of diabetic drugs, and to assess the incidence of complications in diabetes mellitus.
Methods & Materials: This was a prospective observational study carried out at Dr. B.R. Ambedkar Medical College and Hospital. Data collection form was prepared and study was carried out in Patients with inclusion criterias after they were briefed about the study and oral consent was obtained from them.
Results: 150 patients were included in the study, with females 66.67%. The average age of patients included in the study was 57.97±9.90, belonging to the age group 55-64 years. Out of 150 patients 105 had diabetic complications. Patients with Diabetic Nephropathy CCB 38.71% and the combination of ARB with diuretic 22.58% were prescribed, In patients with cardiovascular diseases they were mostly prescribed with CCB 34.29% followed by Beta-Blockers 20.00%, in patients with cerebrovascular diseases combinations of ARB with Diuretic 30.77% were most prescribed and in diabetic foot CCB 45.83% were prescribed. Managing diabetes, Metformin was the most prescribed as mono-therapy in 24.49% patients and as the combination with Glimepiride was used in 56.46% patients.
Conclusion: This study revealed that CCB as monotherapy and ARB with diuretics as dual therapy were the most commonly used agents with diabetic complications like diabetic neuropathy, cardiovascular diseases and diabetic foot. A larger sample size may be necessary to reach a conclusion on the benefits of particular classes of drug in different diabetes complication so as to slower their progression.
Keywords: Antihypertensive drug, Type 2 diabetes, Complications, Hypertension.