Original Research Article
Year: 2017 | Month: July-September | Volume: 2 | Issue: 3 | Pages: 59-65
Prevalence of Sickle Cell Anemia in Pregnancy: A Prospective Study in Tertiary Health Center
Dr. Kuntal Devesh Patel1, Dr. Bhavya Saxena2, Dr. Mansi Balar2, Dr. Sahil Parikh2, Dr. Bhavik Shah2, Dr. Vaibhavi Chaudhari2, Dr. Jasmin Jasani3
1Assistant Professor, 2Resident Student, 3Professor,
Department of Pathology, S.B.K.S.M.I. & R.C., Sumandeep University, Vadodara, Gujarat. 391760
Corresponding Author: Dr. Kuntal Devesh Patel
ABSTRACT
Background: Sickle cell disease comprises a group of diseases characterized by the presence of HbS. It is classified as sickle cell anemia (Hb SS), hemoglobinopathy SC, hemoglobinopathy SD, S-beta thalassemia (Hb S-beta) and other associations of mutant hemoglobin with Hb S. Sickle cell disease is the most common inherited disorder worldwide. Pregnancy in sickle cell disease is at high risk.
Methods: This prospective study was conducted on pregnant females OPD in DGH from 1st January to 1st April 2017. Consenting participants were interviewed using a pre-structured questionnaire. All the data were tabulated according to parameters: age, literacy, anemia, gestational age, parity and HPLC findings.
Result: The total numbers of pregnant women screened for hemoglobinopathy were 2500. 6.4 % had positive sickle solubility tests. Further HPLC analysis was done in the second group and 5.8 % showed hemoglobinopathies. 44.13% were in 1st trimester, 28.96 % were in 2nd trimester and 26.89 % were in last trimester. Majority of the female (57.24%) attended ANC OPD for the first time, out of which 22 (26.50 %) were in first trimester, 41 (49.39%) were in 2nd trimester and the rest of 20 (24.09%) were in last trimester. And there were 62 women visited OPD as followup checkup.
Conclusion: In present study, gravid population has higher prevalence of hemoglobinopathy (5.8 %), mainly SCT (94.48 %). More efforts are required to increase awareness in high risk populations concerning sickle cell anemia before the dream to control hemoglobinopathy in India.
Keywords: Hemoglobinopathy, Sickle cell anemia, Sickle cell trait, Sickle cell Disease, Thalassemia trait